Inhibition of survivin influences the biological activities of canine histiocytic sarcoma cell lines.
Canine histiocytic sarcoma (CHS) is an aggressive malignant neoplasm that originates from histiocytic lineage cells, including dendritic cells and macrophages, and is characterized by progressive local infiltration and a very high metastatic potential.Survivin is as an apoptotic inhibitory factor that has major functions in cell proliferation, incl